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Gastrointestinal side effects are among the most common reasons people find these medications hard to tolerate, especially in the first weeks and while the dose is being increased (Drucker, 2024)
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ERR plays a crucial role in controlling genes involved in oxidative metabolism, mitochondrial biogenesis, and energy production
l-carnitine supplementation decreased DBP (1.162 mmHg, 95% CI: 2.020, 0.303, p = 0.008) without changing SBP levels (0.085 mmHg, 95% CI: 1.455, 1.285, p = 0.903)
However, abnormalities in cholesterol synthesis or metabolism can lead to excessive accumulation in the blood and tissues, thereby increasing the risk of cardiovascular diseases and other metabolic disorders (62, 63)
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